Recent Weizmann Institute studies are revealing a complex picture of cancer progression in which certain genes that drive tumor growth in the earlier stages get suppressed in later stages - taking a step back to move forward. Current research in the lab of Prof. Avri Ben-Ze'ev of the Molecular Cell Biology Department suggests that the tumor cells at the invasive front of later-stage human colorectal cancer may take an even bigger step back: Some of their gene expression patterns are shared with those of healthy intestinal stem cells.
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